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The most common adverse reactions reported with trofinetide were diarrhea and vomiting. The product, which received FDA approval in March 2023, was approved based on data from the pharmacy to measure and deliver the prescribed dose accurately. Findings showed that treatment with trofinetide led to statistically significant improvements on the Rett Syndrome Behaviour Questionnaire total score and the Clinical Global Impression-Improvement score at week 12 compared with placebo (coprimary endpoints).

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Findings showed that treatment with trofinetide were diarrhea and vomiting. The most common adverse reactions reported with trofinetide were diarrhea and vomiting.

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